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KMID : 0359720080260040341
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Journal of the Korean Neurological Association
2008 Volume.26 No. 4 p.341 ~ p.346
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Comparative Cognitive Effects of Levo-Dopa Plus Carbidopa and Dopamine Agonist as an Initial Therapy of Parkinson’s Disease
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Park Jae-Han
Lee Dong-Kuck
Kwon Oh-Dae
Choi So-Young
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Abstract
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Background: Cognitive impairments are common in patients with Parkinson’s disease (PD). However little is
known about the cognitive effects of dopaminergic therapy.
Methods: The study was a single-blind prospective study of 21 patients with PD. Each patient had received either
levodopa (Sinemet®, n=8) or dopamine agonist (Requip®, n=13) during 24 consecutive weeks. Neuropsychological
battery, including Korean version of Alzheimer’s Disease Assessment Scale ? cognitive subscale (ADAS-Cog) and
frontal-executive function part of SNSB (Seoul Neuropsychological Screening Battery), were performed two times,
before and after the 24 weeks of management. Patients also received quantitative ratings of motor symptom
severity and functional status using Unified Parkinson’s Disease Rating Scale (UPDRS) before and after the
dopaminergic therapy.
Results: After six months of treatment, motor scale improved in both groups (p<0.05) without difference between
the groups (p>0.05). In ADAS-Cog testing, Requip® group improved at more categories than Sinemet® group but without
statistical difference (p>0.05). The results of frontal-executive function test did not differ between the groups, either.
Conclusions: Our study does not provide an evidence that dopaminergic treatment improves cognitive functions
in Parkinson’s disease. Furthermore, we found no significant difference in the effect on cognition between the two
tested drugs and no difference in the results of the above-listed neuropsychological tests between the first and the
last visits. J Korean Neurol Assoc 26(4):341-346, 2008
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KEYWORD
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Parkinson’s disease, Levo-dopa, Dopamine agonist, Cognitive function
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